Hypothyroidism 101: Does LT4 Correct All Aspects of Hypothyroidism?

Hypothyroidism 101: Does LT4 Correct All Aspects of Hypothyroidism?

Hypothyroidism 101: Does LT4 Correct All Aspects of Hypothyroidism?

Hypothyroidism 101: Does LT4 Correct All Aspects of Hypothyroidism?

JCEM Dec 2018 103(12) 4533-42

A review

E.A. McAninch et al

Dr.Guttler’s Comments:

  1. Monotherapy with LT4 only failed to correct the Low density lipoprotein LDL and total cholesterol TC.
  2. All other markers tested normalized with LT4.
  3. No one knows if this small amount of LDL or TC is clinically significant.
  4. Before changing to combination T4/T3 therapy more studies have to show it is significant.
  5. Also other biologic markers need to be studied before any change in recommendations for treatment.
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