The Italians Land an FDA Approved Liquid Hypothyroid Treatment in the USA.

The Italians Land an FDA Approved Liquid Hypothyroid Treatment in the USA.

The Italians Land an FDA Approved Liquid Hypothyroid Treatment in the USA.

The Italians Land an FDA Approved Liquid Hypothyroid Treatment in the USA.

The Italians Land an FDA Approved Liquid Hypothyroid Treatment in the USA.

FDA approves Liquid T4 for hypothyroidism and TSH suppression

Levothyroxine, the synthetic form of the thyroid hormone thyroxine, is used in all cases of thyroid deficiency. It is on the list of the World Health Organization’s essential medicines, and is among the most effective, safe, basic and one of the three most widely prescribed medications in the world, as well as the second most prescribed in the U.S. It is also used in the treatment of children in cases of congenital hypothyroidism, and it is important to evaluate whether it may be required in pregnancy, as thyroid hormone deficiency can cause miscarriage and adversely affect a child’s neurological development.

       “Hypothyroidism, explains Leonard Wartofsky, M.D., MACP, past president of the American Thyroid Association, is widespread in the U.S.: it is estimated to affect at least 6% of the population and the most frequent cause is chronic autoimmune thyroiditis. The disease, if not identified and properly treated, is associated with a greater cardiovascular risk, infertility and complications in pregnancy and of the foetus. Thyroxine was identified in 1914 at the Mayo Clinic by Edward Calvin Kendall, as extracted from porcine thyroid, and was made available in the United States from 1927. It only became available in the synthetic form, which ensures a precise measure of the hormone, in 1950. The synthetic form, traditionally produced in tablets, has now undergone a major innovation after 70 years with the development of the liquid form. The precise observance of the recommended dose of levothyroxine is essential to health. The absorption of levothyroxine by the body is affected by interference from gastritis, coeliac disease, lactose intolerance and the intake of certain foods such as coffee and medications such as commonly taken antacids.”

Clinical trials in Italy have demonstrated that with liquid levothyroxine, the requirement of waiting an hour before eating breakfast may be avoided. Many frequently used medications, such as antacids or proton pump inhibitors, do not appear to interfere with absorption of the liquid preparation. And this preparation is certain to enjoy popularity with its application for the treatment of patients who cannot swallow or who are fed by tube, or for children with hypothyroidism.

Comments: Bravo to the Italians!

This new liquid form of T4 will be used for patients with problems with absorption. However, few of my patients need this, as they absorb the pill without problems.

Richard Guttler MD,FACE,ECNU

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