Thyroid Function and Longevity: Protective effect of Higher TSH with Aging
1.Free T4 and Free T3 are minimally decreased or no change with age.
- TSH increases with age. TSH distribution curve shifts to higher mean TSH with age. Age 20 1.4 age 80 3.0 Peak Normal TSH age 20 4.0 Age 80 10.0.
- 14% of age 80 healthy patients have TSH above normal reference range of 4.5.
- Age specific TSH limits would reduce miss classification of patients outside their age specific sub-population.
- TSH changes with age may be genetically determined.
- A higher TSH with aging might contribute to longevity.
- Low thyroid activity is a inheritable trait that could lead to family longevity.
- Multiple effects of lower hormones: decreased metabolism,decreased core body temperature, lower oxygen consumption, and reducing oxidative damage may play a key role in longevity.
This female is 90 years old and is healthy.
We do not know what her TSH is but it may be higher that the accepted normal range for younger females.