Thyroid in Pregnancy 101:Serum TSH How, when and why?
Serum TSH determinations in pregnancy: How, when and why?
- September 2010
- Nature Reviews Endocrinology 6(9):526-9
- Carole Spencer et al
Comments by Dr.Guttler
- TSH is the first line thyroid function test in pregnancy.
- A single serum TSH is the most sensitive index of thyroid function.
- Normal thyroid function is important to ensure the best possible pregnancy outcome.
- Thyroid diseases are relatively frequent in women of childbearing age.
- TSH can detect subtle thyroid function abnormalities in pregnancy.
- Such as overt and subclinical hypothyroidism and hyperthyroidism.
- Poor pregnancy outcomes occur with all thyroid function abnormalities.
- TSH should be drawn in all pregnant women.
- What to do in clinical practice?
- Abnormal TSH is the clue to get FreeT4, FreeT3 and Thyroid Antibodies for autoimmune disease and subclinical hypo or hyperthyroidism.