Can F.I.S.H tell a Hurthle Cell Neoplasm from Benign Hurthle Cell Proliferation? Too early to tell if it has value

Can F.I.S.H tell a Hurthle Cell Neoplasm from Benign Hurthle Cell Proliferation? Too early to tell if it has value

Can F.I.S.H tell a Hurthle Cell Neoplasm from Benign Hurthle Cell Proliferation?

 

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Dr.Guttler’s Comments ion this article.

  1. All non-neoplastic nodules were benign by F.I.S.H.
  2. 7/9 Hurthle cell adenomas were positive by F.I.S.H.
  3. 9/12 carcin0mas were positive by F.I.S.H
  4. F.I.S.H is a method of evaluating 5,7,and 12 chromosomal abnormalities in thyroid nodules.
  5. Too early to tell if it has value. Need more research

SM Bibbey et al  J. Amer.Soc. Cytopathology 2018(7) 195-200

Fluorescence in Situ hybridization (F.I.S.H) of  thyroid fine needle biopsies can tell the difference between neoplastic and non-neoplastic Hurthle cell nodules.

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Above: Non-neoplastic Hurthle cell nodule with no evidence of chromosomal abnormalities seen in B.

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D shows chromosomal abnormalities of # 5 and 7 in a Hurthle cell neoplasm.

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