How Good is a Suspicious Afirma test result in detecting thyroid cancer? Not too good compared to thyroid cytology.
Roychoudhury et al Diag Cytopathol: Feb. 2017
Afirma is effective in determining a benign nature of a nodule. However, a suspicious result does not do the same for diagnosis of cancer. 69 cases studied had suspicious Afirma result. 11/60 had cancer or 82% were benign at surgery and only 18% were cancers.The rate of cancer with a cytology result of suspicious for neoplasm was double 5/16 or 32% the Afirma rate. Afirma suspicious had a false positive rate of 56% 32/57. Suspicious for neoplasm cytology was better than a suspicious Afirma test in predicting cancer.
Comment: Afirma alone is not a good test when the result is suspicious but is good at detecting benign nodules when the result is benign. A novel test from Interpace combines molecular marker testing ThyGen X with a reflex classifier similar the Afirma.
Richard Guttler MD,FACE,ECNU