Molecular Markers for Thyroid Cancer

Molecular Markers for Thyroid Cancer

Molecular Markers for Thyroid Cancer

Molecular Markers for thyroid cancer are not all the same. If you have an indeterminate needle biopsy result and a molecular marker result of a RAS mutation it is only 60% positive for a low grade thyroid cancer. This result should not cause you to have a total thyroidectomy. A lobectomy should be the operation of choice. It is less risky and 1/3 of the time the result is that you have a RAS+ benign adenoma and not cancer. Indeterminate results on needle biopsies should have 7 marker needle washout including

BRAF,RET/PTC,RAS.

The classifier should be a reflex if their are no cancer markers and if it is benign, conservative follow up not surgery is indicated.

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