Thyroglobulin (TG) What You Need to Know.Part 1

Thyroglobulin (TG) What You Need to Know.Part 1

Thyroglobulin (TG) What You Need to Know.Part 1
  1. Thyroglobulin (TG) What You Need to Know.Part 1
  2. TG is the macromolcular precursor of thyroid hotmone production in the gland.
  3. TG is released into the circulation in everyone with a thyroid gland.
  4. TG is the key auto-antigen in autoimmunity.
  5. Genetic defects in TG can cause goiters, and congenital hypothyroidism.
  6. TG is used as a tumor marker in postoperative differentiaThyroglobulin (TG) What You Need to Know.Part 1ted thyroid cancer.
  7. TG result variation of >30% prevents using different assays on the same patient.
  8. TG IMA assays are prone to TG-AB interference in 20% of cases.
  9. TG IMA assays also read too high or too low due to human anti-mouse antibody ( HAMA ).
  10. TG values in serum are a net sum of a.thyroid or tumor mass b. any injury or inflammation  fine needle biopsy of thyroid nodules, surgery,Radioiodine, thyroiditis, c. TSH induced increases in TG.
  11. TG increases in goiter simple goiter iodine deficient goiter and cases of thyroid cancer.
  12. TG decreases to 0 in agenesis, and low in post surgery, and thyroid atrophy.
  13. TG can show a rise with relapse of goiter growth or recurrent cancer.
  14. TG correlates with lymph node mass or recurrence of thyroid cancer.
  15. TG is poorly secreted from lymph nodes and may be undetectable when serum TG is present in cancer.
  16. TG + ultrasound neck imaging are both needed in cancer monitoring.
  17. Thyroid injury of any kind raises the serum TG. Needle biopsy and thyroid surgery cause rapid rise hours followed by decay based on 3 day half life 30 days.
  18. Radioiodine slow rise days-weeks and slower resolution Months.
  19. Thyroiditis causes very slow rise that lasts for 1-2 years.
  20. TSH induced rise in TG of 10-20 fold occurs when withdrawal of T4 occurs for thyroid cancer testing.
  21. Chronic TSH suppression causes the TG to decrease by 50%.
  22. TG is high in Graves’ disease by RIA but low in IMA assays do to antibody interference.
  23. Children by puberty have a normal TG.
  24.  Mothers who smoke have bigger thyroid glands and higher TG in their infants. due to thiocyanate.
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