Researchers performed extended follow-up of a previously reported Late Effects Study Group cohort, including 1,136 patients who were diagnosed with Hodgkin lymphoma (HL) before age 17 years between 1955 and 1986, to detect those childhood HL survivors who were at the highest risk for subsequent malignant neoplasms (SMNs), with a goal to create evidence for risk-based screening recommendations. At 40 years after a diagnosis of HL, the cumulative incidence of any solid SMN (sSMN) was 26.4%. An HL diagnosis between ages 10 years and 16 years and receipt of chest radiotherapy conferred risk for breast cancer among females, while highest risk of developing lung cancer was noted among males treated with chest radiotherapy at age <10 years. The highest risk of developing colorectal cancer was seen in HL survivors who were treated with abdominal/pelvic radiotherapy and high-dose alkylating agents, and highest risk of thyroid cancer was observed in females exposed to neck radiotherapy at age <10 years. Overall, an increased risk of sSMNs was evident among survivors of childhood HL.