Thyroid Cancer 101: “Liquid Biopsy” Can a simple blood test detect thyroid cancer? No, not at present according to this study.

Thyroid Cancer 101: “Liquid Biopsy” Can a simple blood test detect thyroid cancer? No, not at present according to this study.

Thyroid Cancer 101: “Liquid Biopsy” Can a simple blood test detect thyroid cancer? No, not at present according to this study.

Is Measurement of Circulating Tumor DNA of Diagnostic Use in Patients with Thyroid Nodules? Mark Lupo M.D1., Richard Guttler M.D2., Zsofia Geck M.D2, Anja Kammesheidt, PhD3, Theresa Tonozzi, M.P.H.3, and Glenn D. Braunstein M.D3

Goal: Several authors have detected a mutant form of BRAF, BRAFV600E, in the plasma of patients with papillary thyroid carcinoma, with conflicting results (8,9-16). Using a 96 ctDNA mutation panel for nine cancer driver genes, we recently found a BRAF and a GNAS mutation in 2 of 11 (18.2%) plasma samples from patients with thyroid cancer (17). Each of the prior studies studied patients with known thyroid cancer. In order to determine the utility of ctDNA measurements as an adjunct to FNAB in patients with thyroid nodules but without a preexisting diagnosis of thyroid cancer, we examined the plasma of patients undergoing FNAB for the presence of mutations in BRAF, CTNNB1, EGFR, FOXL2, GNAS, KRAS, NRAS, PIK3CA and TP53 using the 96 mutation panel.
Comment:
This negative study failed to find any circulating mutations in thyroid nodule patients undergoing thyroid biopsies.
Add Your Comment

Contact Info
1328 16th Street, Santa Monica, CA 90404
Monday – Friday
9:00 AM to 5:00 PM
(310) 393-8860