Thyroid Cancer 101: Persistence of Thyroglobulin Antibody (TG AB ) for Years Not A Sign of Recurrence.
Martone A et al
Thyroid 28(7) 2018 p.871
Dr.Guttler’s comments on this article.
- It takes years for the TGAB to decline in patients with thyroid cancer treated with total thyroidectomy and no RAI/131.
- Lymphocytic infiltration and slow the decline.
- Elevation of TGAB late may be recurrence or just be regrowth of normal thyroid not cancer.
- TGAB at first post op visit of < 60 was a good indicator of disappearance of
TGAB by 6 years.
Persistent cancer marker TGAB should not be used to give radioiodine or more surgery
if it is declining over 6 years. Rising TGAB can still be just regrowth of thyroid tissue not cancer.
All 107 patients were recurrence free at 6 years.
Call me for evaluation before anymore surgery or radiation.