What is Replacement Normal Thyroid Function For a Patient Without a Thyroid Gland on T4 Monotherapy?
Ito Mitsuru et al Thyroid. April 2017, 27(4): 484-490
133 with papillary thyroid carcinoma after total thyroidectomy.
In the patients with mildly suppressed TSH (0.03 < TSH ≤0.3 μIU/mL) and fT3 levels equivalent to their preoperative levels, all metabolic markers remained equivalent to their preoperative levels. The serum biochemical markers of thyroid function in patients on LT4 following total thyroidectomy suggest that the patients with mildly suppressed TSH levels were closest to euthyroid. Whereas those with normal TSH levels were mildly hypothyroid and those with strongly suppressed TSH levels were mildly hyperthyroid. These data may provide novel information on the management of patients following total thyroidectomy for thyroid cancer or benign thyroid disease.
Comment: T4 therapy with TSH between 0.03-0.3 was associated with normal biochemical markers, whereas TSH lower was associated with hyperthyroid markers, and above 0.3 was associated with hypothyroid makers.