Hyperthyroidism 101: What Causes The Thyroid Cells to Go Wild Forming a Toxic Thyroid Nodule?

Hyperthyroidism 101: What Causes The Thyroid Cells to Go Wild Forming a Toxic Thyroid Nodule?

Hyperthyroidism 101: What Causes The Thyroid Cells to Go Wild Forming a Toxic Thyroid Nodule?

Hyperthyroidism 101: What Causes The Thyroid Cells to Go Wild Forming a Toxic Thyroid Nodule?

Dr.Guttler’s comments: Treatment for Toxic nodules was first surgery, then radio iodine and now outpatient radiofrequency ablation RFA shown below can cure the disease without the need for thyroid hormone after.

Call me to have an evaluation to see if you are a candidate for this procedure.310-393-8860 or email to thyroid.manager@protonmail.com.

 

1.Autonomous functioning thyroid nodules AFTN are the most common benign tumors of the thyroid gland.

2. They make slightly too much thyroid hormone on the way sometimes after years to become Toxic thyroid nodules TTN.

3.DNA mutation in two genes account for around 70 percent of all AFTNs.

4.Hyperthyroidism has several detrimental effects in the affected patients.

5.Symptoms include persistent restlessness, irritability, insomnia, inexplicable weight loss, excessive sweating and an increased pulse.

6.Untreated hyperthyroidism has severe consequences, including, most importantly, a higher mortality for cardiovascular disease.

7.Hyperfunction is triggered by thyroid tumours, most of which are benign. Among them, the so-called autonomous adenoma  AFTN accounts for the majority.

8. Recent study examined 19 autonomous adenomas using sequencing of the part of the gene that translates into proteins ( exons).

9.A mutation in a gene is involved in controlling cell proliferation and differentiation.

10.The gene mutation  EZH1 causes increased thyroid cell proliferation and formation of autonomous nodules.

11.A Two-hit model for AFTN is the first mutation increases the disposition for the formation of tumours, whereas the second EZH1 triggers the hyperthyroidism in the toxic nodule.

 

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