1.Thyroid nodules (TNs) usually appearing in the general population have the potential possibility of malignant transformation and common problems of jugular oppression such as dyspnea and hoarseness.
2. Meta-analysis of data from 1090 patients with 1406 benign TNs in 20 articles.
3. Nodule volume, they were significantly decreased at 1, 3, 6, 12, and the last follow-up months, when comparing post-RFA with the initial nodule volume.
4. The volume also notably declined by cold and hot nodules.
5. Largest diameter, symptom score, cosmetic score, thyrotropin, triiodothyronine, free thyroxine level, and vascularity, the pooled data indicated that there was a decrease in largest diameter, symptom score, cosmetic score, triiodothyronine level, and vascular scale, an unchanged free thyroxine, and an increased thyrotropin level after RFA.
6. In summary, by pooling of these studies we recommended that RFA indeed has the advantages in improving outcomes and providing better prognosis for patients with benign TNs.
7. The pooled meta-analysis of included studies demonstrated significant differences in nodule volume, largest diameter, symptom score, cosmetic score, TSH, T3, fT4, and vascularity before and after RFA for patients with benign TNs.
8. RFA has the advantages of improving outcomes and providing better prognosis for patients with benign TNs.