Benign Thyroid Diseases of of hyperthyroidism, and Hashimoto’s thyroiditis have Increased Risk of Thyroid Cancer

Benign Thyroid Diseases of of hyperthyroidism, and Hashimoto’s thyroiditis have Increased Risk of Thyroid Cancer

Benign Thyroid Diseases of of hyperthyroidism, and Hashimoto’s thyroiditis  have Increased Risk of Thyroid Cancer

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Hashimoto’s thyroiditis after before and treatment.

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Graves Disease

DR.Guttler’s Comments on this article

1.We have know for a long while that increased risk of differentiated thyroid cancer, including regional/distant disease, following diagnosis of hyperthyroidism is do to the Thyroid Stimulating Antibody of Graves’ disease stimulating the thyroid cancer nodule growth.Antibody stimulation of the gland that mimics TSH.

2. Hashimoto’s have high TSH for many years before the patient becomes hypothyroid can cause nodules and cancer to grow slowly.

3. This is not due solely attributed to increased medical surveillance.

4. Hypothyroidism alone not due to Hashimoto’s was less clearly associated with thyroid cancer risk.

Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study

The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 6, 1 June 2018, Pages 2216–2224, https://doi.org/10.1210/jc.2017-02599
Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.
Objective

To examine thyroid cancer risk after diagnoses of a wide range of benign thyroid conditions.

Design

Hospital and cancer registry linkage cohort study for the years 1978 to 2013.

Setting

Nationwide (Denmark).

Participants

Patients diagnosed with hyperthyroidism (n = 85,169), hypothyroidism (n = 63,143), thyroiditis (n = 12,532), nontoxic nodular goiter (n = 65,782), simple goiter (n = 11,582), other/unspecified goiter (n = 21,953), or adenoma (n = 6,481) among 8,258,807 residents of Denmark during the study period.

Main Outcome Measures

We computed standardized incidence ratios (SIRs) for differentiated thyroid cancer, excluding the first 12 months of follow-up after benign thyroid disease diagnosis.

Results

SIRs were significantly elevated for all benign thyroid diseases apart from hypothyroidism. SIRs were higher for men than women and in the earlier follow-up periods. Elevated SIRs were observed for localized and regional/distant thyroid cancer. After excluding the first 10 years of follow-up, hyperthyroidism [n = 27 thyroid cancer cases; SIR = 2.00; 95% confidence interval (CI): 1.32 to 2.92], nontoxic nodular goiter (n = 83; SIR = 4.91; 95% CI: 3.91 to 6.09), simple goiter (n = 8; SIR = 4.33; 95% CI: 1.87 to 8.53), other/unspecified goiter (n = 20; SIR = 3.94; 95% CI: 2.40 to 6.08), and adenoma (n = 9; SIR = 6.02; 95% CI: 2.76 to 11.5) remained positively associated with thyroid cancer risk.

Conclusions

We found an unexpected increased risk of differentiated thyroid cancer, including regional/distant disease, following diagnosis of hyperthyroidism and thyroiditis that could not be solely attributed to increased medical surveillance. Hypothyroidism was less clearly associated with thyroid cancer risk.

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