Hashimoto’s ( CHT ) Nodules and Thyroid Cancer 101:
Increased Risk with Nodules in CHT.
Goiter in CHT which could harbor a thyroid cancer. Read below.
1. CHT can make it a difficult diagnosis when there are thyroid nodules.
2. Hurthle cell metaplasia is common in CHT and can
be confused with Hurthle cell neoplasm.
3. Also long standing untreated subclinical hypothyroidism ( TSH 3-10)
with positive antibodies have a rising TSH stimulation to the gland that
can foster nodule growth.
4. Nodules in CHT patients had more indeterminate biopsy results.
5. They had a higher rate of cancer as well.
6.The risk of any nodule proving malignant was significantly elevated
in the setting of CHT.
7. the old saw that multiple nodular goiter was lower risk is not true.
8. The number of nodules in CHT did not change the increased risk of cancer.
9. Hashimoto’s thyroiditis increases the risk of thyroid malignancy in any patient presenting for nodule evaluation.
10. CHT causing diffuse sonographic heterogeneity and/or TPOAb positivity should be used for risk assessment at time of evaluation.
The Impact of Hashimoto’s Thyroiditis on Thyroid Nodule Cytology & Risk of Thyroid Cancer
- Nathalie Silva de Morais et al