Thyroid Nodules 101: Outside Second Opinion on Thyroid Needle Biopsy Slides. Saves unnecessary surgery.
Dr.Guttler’s comments on this important paper.
1.331 thyroid FNA biopsy specimens obtained from outside centers reviewed.
2. 66% (218/331) agreed with the diagnosis.
3.14% did not agree about DX of cancer.
4.Concordance in the 129 patients with indeterminate FNA biopsies was only 37% (48/129).
5. Indeterminate FNA biopsies were reread as nondiagnostic in 21% (27/129) of patients and as benign in 42% (54/129) of patients.
6.Indeterminate FNA biopsies on initial cytology had a malignancy rate of 13% (17/129) on operative pathology compared with 29% (14/48) for indeterminate FNA biopsies from second opinion.14% did not have cancer on second opinion. 53% of indeterminate cases had a different diagnosis on second opinion. 43% of intertermanate had a definite benign result