A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism.

A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism?

Too early to tell but worth discussing.

J Clin Endocrinol March 2020 195(3) :696-704

GJ Kahaly et al

Dr.Guttler’s comments:

1. 15 patients were treated with monoclonal antibody Iscalimab.
2.  7/15 became euthyroid.
3.  2/15 had normal TSH.
4.  6/15 needed ATD therapy.
5. 34/39, adverse effects were mild.
6.  5/39 moderate.
7.  SX =Fatigue , nausea, headache, URI and cystitis.
8.  Iscalimab is generally safe and clinically effective in a group of patients with GD.
9.  An alternative to the toxic drugs Tapazole and PTU in some patients in the future will be a good resource to add to the long standing use of ATD’s,