A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism.

A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism.

A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism.

A Novel Drug to Replace Tapazole and PTU for Graves’ hyperthyroidism?

Too early to tell but worth discussing.

J Clin Endocrinol March 2020 195(3) :696-704

GJ Kahaly et al

Dr.Guttler’s comments:

  1. 15 patients were treated with monoclonal antibody Iscalimab.
  2.  7/15 became euthyroid.
  3.  2/15 had normal TSH.
  4.  6/15 needed ATD therapy.
  5. 34/39, adverse effects were mild.
  6.  5/39 moderate.
  7.  SX =Fatigue , nausea, headache, URI and cystitis.
  8.  Iscalimab is generally safe and clinically effective in a group of patients with GD.
  9.  An alternative to the toxic drugs Tapazole and PTU in some patients in the future will be a good resource to add to the long standing use of ATD’s,
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